Horton hears a hit.

The computer-animated adaptation "Dr. Seuss' Horton Hears a Who!" trampled its rivals at the box office with weekend sales of $45.1 million, the biggest opening of the year.

The 20th Century Fox release, which boasts the voices of Jim Carrey and Steve Carell, exceeded industry expectations but fell short of the $55.1 million bow of Carrey's previous turn in a Seuss movie, 2000's "How the Grinch Stole Christmas."

The previous weekend's No. 1 movie, action yarn "10,000 B.C.," slipped to second place with $16.4million, raising its 10-day total to $61.2 million.

"Never Back Down," about a troubled youth who finds purpose in the sport of mixed martial arts fighting, opened in third place with $8.6 million.

The weekend's other new wide release, the horror thriller "Doomsday," premiered at No. 7 with $4.7 million.

Coming in at No. 4 was the Martin Lawrence comedy "College Road Trip," with the political thriller "Vantage Point" hitting No.5.

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